Induction Chemotherapy with Cisplatin, Fluorouracil, and Cetuximab in Locally Advanced Head and Neck Cancer

We conducted a non-randomized retrospective study of the treatment locally advanced head and neck squamous-cell carcinoma (LA-SCCHN), comparing induction chemotherapy (ICT) with cetuximab plus cisplatin fluorouracil (FPE) docetaxel (TPF), followed by radiotherapy cetuximab. non-randomly assigned 24 patients (all whom had N stage N2 or N3 no distant metastases were candidates for organ preservation) to receive either FPE- TPF-ICT, evaluated efficacy safety. The overall response rate, one-year progression-free survival, survival comparable between FPE TPF arms. Hematological toxicities during ICT more pronounced in arm than arm. No grade 4 5 adverse events observed Patients LA-SCCHN who received FPE-ICT fewer hematological compared TPF-ICT. may be viable alternative standard TPF-ICT LA-SCCHN.